After the sex scandal, Hamilton’s political career is on the rocks but it’s on a personal level that he is truly rocked when his son dies in a duel. The musical takes a somber turn as he and Eliza deal with the loss and eventually reconcile.
Then it’s back to politics, and Hamilton’s fateful decision to support Thomas Jefferson over Aaron Burr in the 1800 election. Jefferson wins, Burr is consumed with jealous rage and pins all of his failures on Hamilton, whom he challenges to a duel. You all know how that turns out.